Artículos Científicos y
Tratamientos Actuales
con Células Madre.

Tratamientos con Células Madre

Los tratamientos consisten en reemplazar las células enfermas y disfuncionales por células saludables y funcionales. La generación de tejidos humanos es hoy una realidad y la regeneración de órganos completos está cada vez más cerca.

Por su potencial de diferenciación y reproducción, las Células Madre pueden tratar diferentes condiciones.

La mayoría de estos tratamientos están registrados en la página oficial de Protocolos Clínicos del Instituto Nacional de Salud de los Estados Unidos (www.clinicaltrials.gov) mismo que sirve como referencia para millones de pacientes alrededor del mundo que están en busca de novedosos tratamientos para la cura de muchas enfermedades.Leer más

Todos los pacientes que cumplan los criterios de elegibilidad establecidos por el médico tratante en cada protocolo son elegibles para realizarse estos tratamientos inmediatamente. Incluso en México la COFEPRIS ya expide permisos para el uso de Células Madre Mesenquimales en humanos.

Artículos Científicos

A continuación encontrarás algunos documentos científicos (en formato .pdf) sobre las Células Madre y sus diferentes aplicaciones en distintas áreas de la medicina.

Células Dentales (Mesenquimatosas)
Banking Stem Cells from Human Exfoliated Deciduous Teeth (SHED): Saving for the Future
Vipin Arora * / Pooja Arora** / AK Munshi***

Stem Cells:Sources, Therapies and the Dental Professional
Jeremy J. Mao, DDS, PhD and Fiona M. Collins, BDS, MBA, MA

“Opening” The Mesenchymal Stem Cell Tool Box
Fares Zeidán – Chuliáa Mami Nodab.

Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine
G.T.-J. Huang, S. Gronthos and S. Shi.

Human Mandible bone defect repair by the grafting of Dental Pulp Stem/Progenitor Cells and Collagen Sponge Biocomplexes
Riccardo d’Aquino, Alfredo De Rosa, Vladimiro Lanza, Virginia Tirino, Luigi Laino, Antonio Graziano, Vincenzo Desiderio, Gregorio Laino and Gianpaolo Papaccio.

Aislamiento y caracterización parcial de Células Madre de Pulpa Dental
Magallanes Fabián Miriam, Carmona Rodríguez Bruno, Álvarez Pérez Marco Antonio.

Isolation of Distinct Progenitor Stem Cell Populations from Dental Pulp
Waddington RJ, Youde SJ, Lee CP, Sloan AJ.

Isolation and characterization of dental pulp stem cells from a supernumerary tooth
Huang AH, Chen YK, Lin LM, Shieh TY, Chan AW.

Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth.
Cordeiro MM, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, Smith AJ, Nör JE.

Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascularization, osteo-, adipo- and neurogenesis
ME Yalvac,M Ramazanoglu, AA Rizvanov1, F Sahin1, OF Bayrak, U Salli, A Palota and GT Kose.

Human Dental Pulp Stem Cells: From Biology to Clinical Applications
Riccardo DÁquino, Alfredo de Rosa, Gregorio Latino, Filippo Caruso, Luigi Guida, Rosario Rullo, Vittorio Checchi, Luigi Laino, Virginia Tirino and Gianpaolo Papaccio.

In vivo evaluation of human dental pulp stem cells differentiated towards multiple lineages
Weibo Zhang1, X. Frank Walboomers1, Toin H. Van Kuppevelt2, Willeke F. Daamen2, Philippe A. Van, Damme3, Zhuan Bian4 and John A Jansen.
Regeneración de Huesos y Estructura Craneofacial
Craniofacial Tissue Engineering by Stem Cells
J.J. Mao, W.V. Giannobile, J.A. Helms, S.J. Hollister, P.H. Krebsbach, M.T. Longaker and S. Shi.

Healing Cranial Defects with AdRunx2-transduced Marrow Stromal Cells
Z. Zhao, Z. Wang, C. Ge, P. Krebsbach and R.T. Franceschi.

Dental Pulp Stem Cells: A Promising Tool for Bone Regeneration
Riccardo d’Aquino; Gianpaolo Papaccio; Gregorio Laino; Antonio Graziano.

Dental and Skeletal Stem Cells: Potential Cellular Therapeutics for Craniofacial Regeneration
Paul H. Krebsbach, D.D.S., Ph.D.; Pamela Gehron Robey, Ph.D.
Problemas Neurológicos
Dental Pulp Cells Produce Neurotrophic Factors, Interact with Trigeminal Neurons in Vitro, and Rescue Motoneurons after Spinal Cord Injury
Irina V. Nosrat, Johan Widenfalk, Lars Olson and Christopher A. Nosrat.

Differentiation of Dental Pulp stem cells into a neural lineage
Masaharu Takeyasu, Tadashigue Nozaki, Michiharu Daito.

Putative Dental Pulp Derived Stem/Stromal Cells Promote Proliferation and Differentiation of Endogenous Neural Cells in the Hippocampus of Mice.
Huang AH, Snyder BR, Cheng PH, Chan AW.

Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues.
Arthur A, Rychkov G, Shi S, Koblar SA, Gronthos S.

Human dental pulp stem cells differentiate into neural crest- derived melanocytes and have label-retaining and sphere-forming abilities.
Stevens A, Zuliani T, Olejnik C, Leroy H, Obriot H, Kerr-Conte J, Formstecher P, Bailliez Y, Polakowska RR.

Putative Dental Pulp-Derived Stem/Stromal Cells Promote Proliferation and Differentiation of Endogenous Neural Cells in the Hippocampus of Mice
Andeson Hsien-Cheng Huangbrooke R. Snyder, Pei-Hsun Cheng, Anthony W.S. Chan.

Stem Cells from Human-Exfoliated Deciduous Teeth Can Differentiate into Dopaminergic Neuron-Like Cells
Jinsong Wang. Xuan Wang.. Zuoli Sun. Xiaomin Wang. Hui Yang. Songtao Shi. and Songlin Wang.

Implanted Adult Human Dental Pulp Stem Cells Induce Endogenous Axon Guidance
Agnieszka Arthur, Songtao Shi, Andrew C. W. Zannettino, Nobutaka Fujii, Stan Gronthos, Simon A. Koblare

Simultaneous PKC and cAMP activation induces differentiation of human dental pulp stem cells into functionally active neurons
Marianna Kira ́lya, Bala ́zs Porcsalmya, A ́gnes Patakib, Kristo ́f Ka ́da ́ra, Ma ́rta Jelitaic, Ba ́lint Molna ́ra, Pe ́ ter Hermann d, Istva ́ n Gera e, Wolf-Dieter Grimm, Bernhard Ganss, A ́ kos Zsembery, Ga ́ bor Varga.

Human Tooth Germ Stem Cells Preserve Neuro-Protective Effects afterLong-Term Cryo-Preservation
Mehmet E. Yalvaç, Mustafa Ramazanoglu, Murat Tekguc, Omer F. Bayrak, Aygul K. Shafigullina, Ilnur I. Salafutdinov, Natalia L. Blatt, Andrey P. Kiyasov, Fikrettin Sahin, András Palotás, and Albert A. Rizvanov.
Diabetes
Differentiation of Dental Pulp Stem Cells Into Islet Like Aggregates
V. Govindasamy et al.

Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets
J. Olerud & N. Kanaykina & S. Vasilovska & D. King & M. Sandberg & L. Jansson & E. N. Kozlova.

Stem cell therapy for type 1 diabetes mellitus: a review of recent clinical trials
Carlos Eduardo Barra Couri and Júlio César Voltarelli.

Stem cell transplantation for type 1 diabetes mellitus
Júlio C Voltarelli and Carlos Eduardo Barra Couri.

Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitros
Sun Yu, CHEN Li, HOU Xin-guo, HOU Wei-kai, DONG Jian-jun, SUN Lei, TANG Kuan-xiao, WANG Bin, Song Jun, LI Hui and WANG Ke-xin.

Mesenchymal Stem Cells from Adult Human Bone Marrow Differentiate into a Cardiomyocyte Phenotype In Vitro
Wenrong Xu, Xiran Zhang, Hui Qian, Wei Zhu, Xiaochun Sun, Jiabo Hu, Hong Zhou, and YongChang Chen.
Regeneración de Piezas Dentales y problemas Periodontales
Dentin Regeneration by Dental Pulp Stem Cell Therapy with Recombinant Human Bone Morphogenetic Protein
K. Iohara, M. Nakashima, M. Ito, M. Ishikawa, A. Nakasima and A. Akamine.

Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
Wataru Sonoyama1, Yi Liu., Dianji Fang, Takayoshi Yamaza, Byoung-Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun-Yu Wang, Songlin Wang, Songtao Shi.

Stem-cell-based Tissue Engineering of Murine Teeth
A. Ohazama, S.A.C. Modino, I. Miletich and P.T. Sharpe.

The efficacy of mesenchymal stem cells to regenerate and repair dental structures
S Shi, PM Bartold, M Miura, BM Seo, PG Robey, S Gronthos

Self-Assembling Peptide Amphiphile Nanofibers as a Scaffold for Dental Stem Cells
Galler KM, Cavender A, Yuwono V, Dong H, Shi S, Schmalz G, Hartgerink JD, D’Souza RN.

Stem cells and periodontal regeneration.
Lin NH, Gronthos S, Bartold PM.

In vitro stem cell cultures from human dental pulp and periodontal ligament: new prospects in dentistry.
Ballini A, De Frenza G, Cantore S, Papa F, Grano M, Mastrangelo F, Tete S, Grassi FR.

Dental Tissue Regeneration
A Mini-Review A.-H. Yen P.C. Yelick
Problemas Cardiacos
Human Dental Pulp Stem Cells Improve Left Ventricular Function, Induce Angiogenesis, and Reduce Infarct Size in Rats with Acute Myocardial Infarction
Carolina Gandia, Ana Armin, A Jose Manuel García Verdugo, et all.

Cardiac Cell Repair Therapy: A Clinical Perspective
Bernard J. Gersh, MBChB, DPhil, FRCP; Robert D. Simari, MD, PhD; Atta Behfar, MD, PhD; Carmen M. Terzic, MD, PhD; and Andre Terzic, MD, PhD.

IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction
Meijing Wanga,Jiangning Tana, Yue Wanga, Kirstan K. Meldrumb, Charles A. Dinarelloc, and Daniel R. Meldruma.

Stem cell therapy for cardiac repair: benefits and barriers
Steven J. Joggerst and Antonis K. Hatzopoulos.

Cartílago y Hueso
Regeneración de Córneas
Corneal Reconstruction with Tissue-Engineered Cell Sheets Composed of Human Immature Dental Pulp Stem Cells
José Álvaro Pereira Gomez et al.

Human immature dental pulp stem cells share key characteristic features with limbal stem cells
B. G. Monteiro, R. C. Serafim, G. B. Melo, M. C. P. Silva, N. F. Lizier, C. M. C. Maranduba, R. L. Smith, A. Kerkis, H. Cerruti, J. A. P. Gomes and I. Kerkis
Lupus
Immunomodulatory properties of stem cells from human exfoliated deciduous teeth
Takayoshi Yamaza1, Akiyama Kentaro1, Chider Chen1, Yi Liu, Yufang Shi, Stan Gronthos, Songlin Wang, Songtao Shi
Cirugía Plástica
Transplantation of Mesenchymal Stem Cells Is an Optimal Approach for Plastic Surgery
Dianji Fang, a Byoung-Moo Seo,b Yi Liu, a Wataru Sonoyama,c Takayoshi Yamaza, c Chunmei Zhang,a Songlin Wang, Songtao Shi.
Músculos
Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases
Farida Djouad, Carine Bouffi, Soufiane Ghannam, Danièle Noël and Christian Jorgensen

Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic?
Kerkis Irina ; Ambrosio Carlos ; Kerkis Alexandre ; Martins Daniele ; Zucconi Eder ; Fonseca Simone ; Cabral Rosa ; Maranduba Carlos ; Gaiad Thais ; Morini Adriana ; Vieira Natassia ; Brolio Marina ; Sant’Anna Osvaldo ; Miglino Maria ; Zatz Mayana
Piel
Cell-Based Cytokine Therapy for Skin Rejuvenation
Minoru Ueda and Yudai Nishino

Stem cells from human exfoliated deciduous teeth (SHED) enhance wound healing and the possibility of novel cell therapy
Yudai Nishino, Yoichi Yamada, Katsumi Ebisawa, Sayaka Nakamura, Kazuto Okabe, Eri Umemura, Kenji Hara & Minoru Ueda

Human deciduous teeth dental pulp cells with basic fibroblast growth factor enhance wound healing of skin defect
Nishino Y, Ebisawa K, Yamada Y, Okabe K, Kamei Y, Ueda M.
Problemas Hepáticos (Hígado)
Deciduous and Permanent Dental Pulp Mesenchymal Cells Acquire Hepatic Morphologic and Functional Feautures In Vitro
Nokolay Ishkitiev et al.

Multipotent cells from the human third molar: feasibility of cell-based therapy for liver disease
Etsuko Ikeda, Kiyohito Yagi, Midori Kojima, Takahiro Yagyuu, Akira Ohshima, Satoshi Sobajima, Mika Tadokoro, Yoshihiro Katsube, Katsuhiro Isoda, Masuo Kondoh, Masaya Kawase, Masahiro J Go, Hisashi Adachi, Yukiharu Yokota, Tadaaki Kirita, Hajime Ohgushi.

Fetal and adult liver stem cells for liver regeneration and tissue engineering
H. C. Fiegel , Claudia Lange, U. Kneser, W. Lambrecht , A. R. Zander, X. Rogiers , D. Kluth
BioEden's research and treatment

Tratamientos Actuales con Células Madre

Sistema Digestívo
Vejiga, Colón y Piel
Sistema Respiratorio
Rechazo de Transplante
Sistema Nervioso
Reconstrucción Post-Cirugía
Cosmética
Sistema Inmunológico
Articulación y Cartílago

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Los tratamientos con Células Madre consisten en reemplazar las células enfermas y disfuncionales por células saludables y funcionales. La generación de tejidos humanos es hoy una realidad y la regeneración de órganos completos está cada vez más cerca.